Table 3.

Biomarkers identified in fecal metabolic profiles of KT group vs. CT group. ^a Area under the receiver operating characteristic (ROC) curve of the biomarkers; ^b sensitivity and ^c specificity were calculated from the ROC curve.

Compound	FDR	FC	AUC a	Sensitivity b	Specificity c	Pathways
Cholestenone	0.00168	1.7408 × 10−5	0.86579	0.77	0.951	Steroid degradation
Triethyl Citrate	0.00147	4.4656 × 10−6	0.84013	0.725	0.921	Not identified
Gamma-Sitosterol	0.0161	3.4307 × 10−5	0.81711	0.709	0.916	Not identified
Cholesterylene	0.0153	2.3588	0.79868	0.684	0.906	Steroid hormone biosynthesis
Ethyl 9,12-hexadecadienoate	0.0133	1.0012 × 10−5	0.78158	0.654	0.906	Primary bile acid biosynthesis; Steroid hormone biosynthesis
Adipic acid	0.00158	21.854	0.77961	0.649	0.891	Caprolactam degradation
Nonyl dichloroacetate	0.00769	9.9808 × 10−6	0.76974	0.657	0.876	Not identified
Dioctyl Phthalate	0.0022	9.0143 × 10−6	0.76908	0.641	0.875	Not identified
Delta-Tocopherol	0.0131	20654.0	0.75395	0.607	0.896	Ubiquinone and other terpenoid-quinone biosynthesis
Cholesterol	0.00675	4.46284	0.74803	0.609	0.866	Steroid hormone biosynthesis; Primary bile acid biosynthesis
Tyrosine	0.00985	57.844	0.74408	0.619	0.859	Ubiquinone and other terpenoid-quinone biosynthesis; Tyrosinemetabolism, Phenylalanine, tyrosine and tryptophan biosynthesis; Aminoacyl-tRNA biosynthesis
m-cymene	0.036354	105790.0	0.74276	0.699	0.866	Not identified
Indole	0.04437	45722.0	0.72763	0.671	0.87	Phenylalanine, tyrosine and tryptophan biosynthesis
Epi-coprostanol	0.0337	10665.0	0.71645	0.685	0.838	Not identified
nonadecane	0.0118	0.29481	0.71645	0.599	0.845	Not identified
Sulfurous acid,hexyl octyl ester	0.00715	0.12937	0.7125	0.566	0.831	Cysteine and methionine metabolism
gamma-tocopherol	0.00421	2.1326	0.71118	0.644	0.778	Ubiquinone and other terpenoid-quinone biosynthesis
Stigmasterol	0.02382	6.593 × 10−5	0.70724	0.656	0.764	Steroid biosynthesis

FC: fold change; FDR: false discovery rates; AUC: Area Under the Curve.