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. 2020 Jul 30;27(7):1014–1026. doi: 10.1177/1352458520943768

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© The Author(s), 2020

This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 2. — Distribution of smoking-associated hyper- and hypomethylated CpGs in multiple sclerosis (MS) patients and healthy controls (HCs) across gene features. Horizontal bar plots representing relative frequencies of hyper- and hypomethylated BS-DMPs associated with smoking in MS and HC, shown as percentage (%) across gene features (TSS1500, TSS200, 1stExon, 5ʹUTR, Body, 3ʹUTR, ExonBnd, and IGR). Enrichment/depletion analysis was performed using chi-square test on frequencies, with P values adjusted for multiple testing (Bonferroni).

*Bonferroni-P_adj < 0.05 compared to smoking-associated BS-DMP profile in HC

**Bonferroni-P_adj compared to smoking-associated BS-DMP profile in HC.

Enriched features are represented by a positive symbol (+) and depleted features are represented by a negative symbol (−).