Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Apr 23;10(5):985. doi: 10.3390/cells10050985

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Combination treatment with mitogen-activated protein kinase-dependent recombinant vaccinia virus (MDRVV) (CD/UPRT-LG) and 5-fluorocytosine (5-FC) increases the therapeutic effect in a mouse model harboring liver metastasis caused by human pancreatic ductal adenocarcinoma cells. (A) Schematic representation of the study design and timeline of tumor growth and viral distribution. (B) The nude mice with liver metastasis were intravenously injected with 1 × 10⁷ PFU of MDRVV (CD/UPRT-LG) on days 0 and 8. Next, 12.5 mg 5-FC was injected intraperitoneally into the mice every day from days 14 to 36, except on days 21 and 29. Survival curves of mice were generated by Kaplan–Meier analysis (n = 6–7) and p values were determined using the log-rank test.