Table 2.
Hepatic parameters related to lipid accumulation, inflammation and hepatotoxicity.
| cc-/bb- | cc-/bb+ | cc+/bb- | cc+/bb+ | |
|---|---|---|---|---|
| ALAT (U/L) * | 150 ± 12 | 130 ± 6 | 158 ± 11 | 137 ± 7 |
| Triglyceride content (nmol/mg tissue) § | 188 ± 11 | 171 ± 10 | 157 ± 7 | 182 ± 6 |
| Cholesterol content (nmol/mg tissue) | 60 ± 3 | 55 ± 3 | 61 ± 4 | 60 ± 2 |
| Tnf (relative expression) § | 1.00 ± 0.08 | 1.92 ± 0.44 | 2.36 ± 0.61 | 1.24 ± 0.23 |
| Il6 (relative expression) § | 1.00 ± 0.12 | 1.70 ± 0.21 | 1.83 ± 0.38 | 1.27 ± 0.19 |
| Ccl2 (relative expression) | 1.00 ± 0.11 | 0.98 ± 0.12 | 1.22 ± 0.12 | 1.11 ± 0.27 |
| Tlr4 (relative expression) | 1.00 ± 0.05 | 1.35 ± 0.26 | 1.71 ± 0.50 | 1.69 ± 0.65 |
| Itgax (relative expression) * | 1.00 ± 0.14 | 0.81 ± 0.06 | 1.19 ± 0.16 | 0.84 ± 0.12 |
| Nox1 (relative expression) *§ | 1.00 ± 0.07 a | 1.01 ± 0.05 a | 1.10 ± 0.07 a | 0.73 ± 0.07 b |
Ob/ob mice were fed a standard diet supplemented with or without berberine or curcumin for 4 weeks (n = 9 for each group). * p < 0.05 for berberine effect, § p < 0.05 for interaction effect (two-way ANOVA). Data with different superscript letters are significantly different at p < 0.05 (Tukey post-hoc test). ALAT, alanine aminotransferase.