Table 3.
Biological activities of mono sulfated steroids.
| No. | Antitumor & Related Activity, (Pa) * | Violation of Lipid Metabolism, (Pa) * | Additional Predicted Activity, (Pa) * |
|---|---|---|---|
| 32 | Antineoplastic (0.845) Chemopreventive (0.834) Apoptosis agonist (0.826); |
Anti-hypercholesterolemic (0.895); Cholesterol synthesis inhibitor (0.776); Atherosclerosis treatment (0.712) |
Hepatoprotectant (0.933) Biliary tract disorders treatment (0.895) Wound-healing agent (0.885) |
| 33 | Chemopreventive (0.821) Antineoplastic (0.805); |
Cholesterol synthesis inhibitor (0.667); Atherosclerosis treatment (0.561) |
Hepatoprotectant (0.859) Antiinflammatory (0.832) |
| 34 | Antineoplastic (0.830) Apoptosis agonist (0.792) Chemopreventive (0.783) |
Atherosclerosis treatment (0.691) Cholesterol synthesis inhibitor (0.682); |
Hepatoprotectant (0.968) Anti-inflammatory (0.817) Biliary tract disorders treatment (0.704); |
| 35 | Chemopreventive (0.777) Antineoplastic (0.779) |
Anti-hypercholesterolemic (0.748) Cholesterol synthesis inhibitor (0.717) |
Anti-ischemic, cerebral (0.850) Biliary tract disorders treatment (0.728) |
| 36 | Chemopreventive (0.821) Antineoplastic (0.765) |
Cholesterol synthesis inhibitor (0.727) Anti-hypercholesterolemic (0.671) |
Biliary tract disorders treatment (0.833) Wound-healing agent (0.794) |
| 37 | Antineoplastic (0.829) | Cholesterol synthesis inhibitor (0.618) | Anti-ischemic, cerebral (0.785) |
| 38 | Antineoplastic (0.813) | Atherosclerosis treatment (0.629) | Biliary tract disorders treatment (0.639) |
| 39 | Antineoplastic (0.823) | Atherosclerosis treatment (0.715) | Biliary tract disorders treatment (0.931) |
| 40 | Chemopreventive (0.924) Antineoplastic (0.837) |
Anti-hypercholesterolemic (0.926) Atherosclerosis treatment (0.671) |
Wound-healing agent (0.953) Hepatoprotectant (0.925) |
| 41 | Antineoplastic (0.854) Apoptosis agonist (0.790) |
Anti-hypercholesterolemic (0.902) Atherosclerosis treatment (0.675) |
Wound-healing agent (0.963) Hepatoprotectant (0.915) |
| 42 | Chemopreventive (0.918) Antineoplastic (0.806) |
Anti-hypercholesterolemic (0.942) Cholesterol synthesis inhibitor (0.712) |
Wound-healing agent (0.975) Hepatoprotectant (0.915) |
| 43 | Chemopreventive (0.935) Antineoplastic (0.818) |
Anti-hypercholesterolemic (0.901) Atherosclerosis treatment (0.685) |
Wound-healing agent (0.980) Hepatoprotectant (0.972) Biliary tract disorders treatment (0.958) |
| 44 | Chemopreventive (0.922) Antineoplastic (0.841) |
Anti-hypercholesterolemic (0.887) Atherosclerosis treatment (0.679) |
Wound-healing agent (0.977) Hepatoprotectant (0.965) |
| 45 | Chemopreventive (0.931) Antineoplastic (0.861); |
Anti-hypercholesterolemic (0.716) Atherosclerosis treatment (0.704) |
Hepatoprotectant (0.893) Wound-healing agent (0.887) |
| 46 | Antineoplastic (0.831) | Anti-hypercholesterolemic (0.782) | Wound-healing agent (0.888) |
| 47 | Chemopreventive (0.860) | Anti-hypercholesterolemic (0.850) | Wound-healing agent (0.861) |
* Only activities with Pa > 0.5 are shown.