Table 1.
Effects of long-term BPA exposure and NAC treatment on body weight, kidney weight, food and water intake.
| Parameters | Week 0 | Week 12 | Week 16 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Veh | BPA | BPA+NAC | Veh | BPA | BPA + NAC | Veh | BPA | BPA + NAC | |
| BW (g) |
135.0 | 135.0 | 134.0 | 459.17 | 415.00 | 415.83 | 466.67 | 396.67 | 395.00 |
| ±1.83 | ±0.62 | ±1.53 | ±5.07 ‡ | ±14.61 *,‡ | ±10.12 *,‡ | ±10.54 | ±4.94 * | ±10.17 * | |
| Food intake | - | - | - | 20.69 | 19.58 | 19.58 | 17.74 | 17.71 | 17.80 |
| (g/day) | ±0.82 | ±0.29 | ±0.28 | ±1.09 | ±0.36 | ±0.12 | |||
| Water intake | - | - | - | 20.12 | 20.45 | 20.27 | 20.52 | 21.58 | 20.30 |
| (ml/day) | ±1.27 | ±1.35 | ±1.02 | ±1.12 | ±0.96 | ±1.59 | |||
| KW | - | - | - | - | - | - | 2.85 | 2.32 | 2.24 |
| (g) | ±0.07 | ±0.01 * | ±0.04 * | ||||||
| KW/BW | - | - | - | - | - | - | 0.61 | 0.59 | 0.59 |
| (* 100) | ±0.02 | ±0.01 | ±0.01 |
Values are mean ± SEM (n = 6 each). Veh: vehicle-treated group; BPA: BPA-treated group; BPA+NAC: BPA plus NAC-treated group; BW: body weight; KW: kidney weight. * p < 0.05 vs. Veh within the same week. ‡ p < 0.05 vs. their respective values in week 0.