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. 2021 Apr 25;10(5):1011. doi: 10.3390/cells10051011

Figure 8.

Figure 8

(A) Schematic showing in vivo work flow in mice after ischemic stroke. (B) Relative miR-141 gene expression analysis in RNA isolated from perilesional cortex of ischemic brain tissues and control (sham) samples (n = 3). (C) Relative miR-141 gene expression analysis in RNA isolated from perilesional cortex of ischemic brain tissues after systemic treatment with indicated nanoparticles on x-axis (n = 7, n = 7, and n = 8 in scrambled control, PS-NP and PNA-NP, respectively). PNA-141-3p NPs significantly (* p < 0.05 vs. Scr-NP) reduces miR-141-3p expression levels in brain tissue of socially isolated stroke mice. MiR-141-3p levels were optimally reduced by PS-141-3p NPs. Data are shown as mean ± standard error mean (SEM), Student T test was used for statistical analysis. * p < 0.05.