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. 2021 Apr 25;10(5):1011. doi: 10.3390/cells10051011

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Anti-miR-141 treatment improves recovery in post-stroke socially isolated mice. (A) Representative coronal section of in vivo treated Scr-control (n = 7), PS-141 (n = 7), and PNA-141 (n = 8) treated brain section by TTC staining. (B) PNA-141 NP treatment significantly reduced infarct volume in post-stroke socially isolated mice compared to Scr-NP (* p < 0.05 vs. Scr-NP). PS-NP show moderate but insignificant reduction of infarct volume. (C) Relative gene expression of inflammatory marker TNF-alpha in the control group and NPs-treated group as indicated. Data are presented as mean ± standard error mean (SEM).