Table 1.
Characterization of PLGA NPs containing antimiR-141 sequences. Mean diameter and polydispersity index (PDI) was calculated using dynamic light scattering (DLS), and the surface charge was calculated using zeta potential.
| Nanoformulation | DLS (nm ± SEM) | PDI (± SEM) | Zeta Potential (mV ± SEM) |
|---|---|---|---|
| Blank-1 | 376.3 ± 09.1 | 0.22 ± 0.03 | −21.03 ± 2.55 |
| PS-141 | 349.5 ± 15.8 | 0.21 ± 0.02 | −19.97 ± 2.71 |
| Scr-PS-141 | 350.6 ± 15.8 | 0.20 ± 0.01 | −18.83 ± 3.45 |
| Blank-2 | 336.3 ± 28.3 | 0.21 ± 0.04 | −24.17 ± 0.64 |
| PNA-141 | 330.9 ± 41.4 | 0.18 ± 0.07 | −18.03 ± 1.07 |
| Scr-PNA-141 | 315.9 ± 28.1 | 0.18 ± 0.07 | −22.03 ± 1.07 |