Table 2.
Disease relevance of HuD.
| Disease | Disease Relevance of HuD | Ref. |
|---|---|---|
| Alzheimer’s diseases (AD) | HuD mRNA and HuD protein ↑ in superior temporal gyrus (STG) of AD patients | [76] |
| HuD protein ↑ in the brain of AD patients | [96] | |
| nELAVL protein ↓ in hippocampus of AD patients | [97] | |
| Parkinson’s diseases (PD) | Several SNPs (rs967582, 2494876, 3902720) were identified. | [98,99,100] |
| Epilepsy | HuD mRNA↑ in dentate gyrus of kainic acid–induced seizures model | [67] |
| Dendritic localization of HuD protein ↑ in hippocampal neurons of pilocarpine–induced seizure model | [101] | |
| Schizophrenia | HuD mRNA ↑ in the dorsolateral prefrontal cortex from patients with chronic schizophrenia | [102] |
| Amyotrophic lateral sclerosis (ALS) | HuD mRNA and HuD protein ↑ in motor cortex of sporadic ALS patients | [80] |
| HuD protein ↑ in human iPSCs carrying the FUSP525L mutation | [103] | |
| Neuroblastoma | HuD mRNA was detected in primary NB tumor samples. | [104] |
| Small cell lung carcinoma (SCLC) | HuD protein ↑ in serum from SCLC patients | [105,106,107] |
| HuD mRNA ↑ in primary tissue from SCLC patients | [108] | |
| HuD mRNA ↑ in blood from SCLC patients | [109] | |
| Oral squamous cell carcinoma (OSCC) | HuD (+) group is associated with poor prognosis of OSCC patients. | [39] |
| Pancreatic neuroendocrine tumor (PNET) | HuD (–) group is associated with poor prognosis of PNET patients. | [90] |
| Type 2 diabetes mellitus (T2DM) | HuD mRNA and HuD protein ↓ in islet from db/db mice | [94] |
↑ means its upregulation (increase). ↓ means its downregulation (decrease).