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. 2021 Apr 27;9(5):481. doi: 10.3390/biomedicines9050481

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Decreased revascularization in 12-week-old mdx mice following hindlimb ischemia (HLI). (a) Under basal conditions, hindlimb blood flow is lower in dystrophic animals; PeriCam measurement; region of interest (ROI); n = 17–19/group. (b) The recovery of blood flow is impaired in mdx mice both 7 days and 21 days after the HLI procedure as shown by representative pictures and a calculation of (c) blood perfusion and (d) blood perfusion rate; n = 11–14/group. The results are presented as mean ± SEM. * p < 0.05, ** p < 0.01 with (a) unpaired two-tailed Student’s t-test or (c–d) with two-way ANOVA with Tukey’s posthoc test.