Table 5.
A list of the developed Antigen-based tests for COVID-19 detection.
| Manufacturer Name | Test Name | Technology | Target Antigen | Sensitivity in Symptomatic Patients | Specificity | Detection | Test Duration |
|---|---|---|---|---|---|---|---|
| Abbott Diagnostics Scarborough, Inc. [132] | BinaxNOW COVID-19 Ag Card Home Test | Colloidal Gold Nanoparticle-Based LFIA, Prescription Home Testing | N antigen | 97.1% | 98.5% | Visual read + submitting the result via the NAVICA mobile application | 15 min |
| Ellume Limited [133] | Ellume COVID-19 Home Test | Fluorescent LF, Over the Counter (OTC) Home Testing, Screening | N antigen | 95% | 97% | Instrument Read (smartphone-based) | 15 min |
| Access Bio, Inc. [134] | CareStart COVID-19 Antigen test | Colloidal Gold Nanoparticle-Based LFIA | N antigen | 88% | 100% | Visual read | 10 min |
| Princeton BioMeditech Corp [135] | Status COVID-19/Flu | Colloidal Gold Nanoparticle-Based LFIA, Multi-analyte | N antigen | 93.9% (LoD: 2.7 × 103 TCID50/mL) | 93.9% | Visual Read | 15 min |
| Celltrion USA, Inc. [136] | COVID-19 Antigen MIA | Magnetic Force-assisted Electrochemical Sandwich Immunoassay (MESIA) | S antigen (RBD domain) | 94.4% (LoD: 3.0 × 101 TCID50/mL) | 100% | Instrument Read | 10 min |
| Quanterix Corporation [137] | Simoa SARS-CoV-2 N Protein Antigen Test | High throughput Paramagnetic Microbead-based Immunoassay | N antigen | 97.70% (LoD: 0.31 TCID50/mL) | Cross-reaction with SARS-CoV | Instrument Read | 80 min |
| Luminostics, Inc. [138] | Clip COVID Rapid Antigen Test | LF immunoluminescent assay | N antigen | (LoD: 0.88 × 102 TCID50/mL) | Cross-reaction with SARS-CoV | Instrument Read (smartphone-based) | 30 min |
| Abbott Diagnostics Scarborough, Inc. [139] | BinaxNOW COVID-19 Ag Card | Colloidal Gold Nanoparticle-Based LFIA | N antigen | 97.1%/22.5 TCID50/mL | 98.5% | Visual Read + submitting the result via the NAVICA mobile application | 15 min |
| LumiraDx UK Ltd. [140] | LumiraDx SARS-CoV-2 Ag Test | FIA | N antigen | 97.6% /32 TCID50/mL | 96.6% | Instrument Read | 12 min |
| Becton, Dickinson and Company (BD) [131] | BD Veritor System for Rapid Detection of SARS-CoV-2 | Chromatographic digital immunoassay | N antigen | 84% | No cross-reaction | Instrument Read | 15 min |
| Quidel Corporation [128] | Sofia SARS Antigen FIA | FIA | N antigen | 87.5% | Cross-reaction with SARS-CoV | Instrument Read | 15 min |
| Quidel Corporation [141] | Sofia 2 Flu + SARS Antigen FIA | FIA | N antigen | (No info) | Cross-reaction with SARS-CoV | Instrument Read | 15 min |