Table 1.

Host factors involved in responses to mosquito-borne viruses.

		RNA Interference	JAK/STAT	Toll	IMD/TNF	Physical Barriers	Adaptive Immunity
Mosquitoes		Dicer-2 AGO2 Drosha R2D2 p400 piwi4 Ppo8	Hop STAT1 Vago vir-1	Toll dMyD88 Dorsal DIF Cactus Spätzle	Relish Caspar Fadd Dredd	Hemocytes Midgut epithelium	N/A
Humans		Dicer AGO Drosha TARBP2 Piwi	JAK STAT1/2 RIG-I MDA5 IFN-α/β	TLRs MyD88 NF-kB IFN-α/β 888IRF7	NF-kB FAF1 Caspase8/10	Blood–brain barrier Epidermis Dermis	B cells T cells

Italicized factors are unique to the specified host or no ortholog exists in the other host.