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. 2021 May 19;22(1):785. doi: 10.3892/etm.2021.10217

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Copyright: © Jia et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Effects of etomidate on the HO-1/Nrf2 pulmonary pathway. (A) HO-1 mRNA expression; (B) Nrf2 mRNA expression; (C) western blot analysis results of (D) Nrf2 and (E) HO-1, expressed as the mean ± SD. ^aP<0.05 vs. CG; ^bP<0.05 vs. MG; ^cP<0.05 vs. EHG; ^dP<0.05 vs. ELG. HO-1, heme oxygenase-1; Nrf2, nuclear factor-erythroid 2-p45-related factor 2; CG, blank control group; MG, model group; ELG, high oxygen exposure + low etomidate dose group (0.3 mg·kg^-1); EMG, high oxygen exposure + moderate etomidate dose group (3.0 mg·kg^-1); EHG, high oxygen exposure + high etomidate dose group (10 mg·kg^-1).