Enantioselective alkylation of pyrroles 8 with α,β-unsaturated 2-acyl imidazoles 4 catalyzed by 1ea.
Reaction conditions: 8 (0.45 mmol), 4 (0.3 mmol), 1e (5 mol%), 4 Å MS (100 mg), CH3CN (3 mL), under argon.
Reaction conditions: 8 (0.45 mmol), 4 (0.3 mmol), 1e (5 mol%), 4 Å MS (100 mg), CH3CN (3 mL), under argon.