Infectivity of modulated AAV2-FITC. Vector genome titers (vg per mL) were measured as indicated in Methods. The ratio vg per GFU obtained from HEK cells was compared; the lower this ratio is, the more infectious the particles are to this cell line. Results are shown as mean ± SD. n = 2 (vg per mL), n = 4 (GFU per mL) and n = 8 (ratio vg per GFU). *p < 0.05 and ***p < 0.001.

	vg per mL	GFU per mL	vg per GFU
Native AAV2	4.60 ± 0.21 × 1012	5.40 ± 0.18 × 109	84.6 ± 4.0
AAV2-FITC (3 × 105 eq.)	1.10 ± 0.0071 × 1011	1.10 ± 0.54 × 109	121.7 ± 52.7
AAV2-FITC (3 × 106 eq.)	2.20 ± 0.014 × 1011	6.20 ± 3.3 × 108	449.8 ± 221.8*
AAV2-FITC (1.5 × 107 eq.)	1.10 ± 0.071 × 1011	1.20 ± 0.47 × 108	999.8 ± 377.1***
AAV2 + fluo (1.5 × 107 eq.)	2.20 ± 0.071 × 1011	1.80 ± 0.41 × 109	122.6 ± 24.0