Table 1.
Major metabolites involved in biogenetics analyzed in the Wt and MitoPPX samples
| Metabolite | LogFC | P-value | FDR | HMDB ID | Metabolic pathway |
|---|---|---|---|---|---|
| G1P/G6P/F6P/F1P | −4.335 | 0.000 | 0.002 | HMDB01401 | Glycolosis/PPP |
| 2/3-Phosphoglyceric Acid | −0.918 | 0.024 | 0.120 | HMDB00362 | Glycolosis |
| NADP | 1.216 | 0.018 | 0.114 | HMDB00217 | Coenzyme |
| NADPH | 2.864 | 0.001 | 0.025 | HMDB00221 | Coenzyme |
| Valine | 0.796 | 0.012 | 0.085 | HMDB00883 | Amino Acid |
| Serine | −0.576 | 0.049 | 0.189 | HMDB00187 | Amino Acid |
| Pentothenate | 2.257 | 0.003 | 0.036 | HMDB00210 | AA metabolism/alanine, CoA |
| 3-hydroxy-3-methylglutarate | −1.333 | 0.005 | 0.050 | HMDB00355 | AA metabolism/Leu |
| N-formylmethionine | 1.586 | 0.011 | 0.081 | HMDB01015 | AA metabolism/Met |
| Taurine | 1.317 | 0.029 | 0.138 | HMDB00251 | AA metabolism/Sulfur metabolism |
| Phosphoserine | −1.758 | 0.037 | 0.163 | HMDB00272 | AA metabolism/Ser |
| UDP-GlcNAc | 1.133 | 0.038 | 0.165 | HMDB00290 | Amino sugar and nucleotide sugar metabolism |
| 2-Hydroxyglutarate | −0.858 | 0.045 | 0.186 | HMDB59655 | AA metabolism & Gly/Ser/Thr metabolism |
| 1/3-Methylhistidine | 1.129 | 0.048 | 0.189 | HMDB00001 | Amino acid metabolism/His |
| AMP | 3.319 | 0.000 | 0.000 | HMDB00045 | Nucleotide |
| GMP | 3.235 | 0.000 | 0.017 | HMDB01397 | Nucleotide/Purine metabolism |
| IMP | 3.526 | 0.001 | 0.025 | HMDB00175 | Nucleotide/Purine metabolism |
| CMP | 3.103 | 0.001 | 0.025 | HMDB00095 | Nucleotide/Pyrimidine metabolism |
| Orotate | −4.184 | 0.002 | 0.030 | HMDB00226 | Nucleotide/Pyrimidine metabolism |
| ADP | 1.690 | 0.002 | 0.030 | HMDB01341 | Nucleotide/Purine metabolism |
| DTMP | 2.482 | 0.004 | 0.048 | HMDB01227 | Nucleic Acid |
| GDP | 1.783 | 0.008 | 0.068 | HMDB01201 | Nucleotide/Purine metabolism |
| Uracil | −0.951 | 0.015 | 0.102 | HMDB00300 | Nucleotide/Pyrimidine metabolism |
| DCMP | 0.930 | 0.022 | 0.120 | HMDB01202 | Nucleotide/pyrimidine |
| UDP | 2.007 | 0.043 | 0.183 | HMDB00295 | Nucleotide/Pyrimidine metabolism |
| 5-Hydroxymethyl-2’-deoxyuridine | 1.757 | 0.003 | 0.041 | N/A | Modified nucleoside |
| 5-Methylcytidine | 3.168 | 0.006 | 0.053 | HMDB00982 | Modified nucleoside |
| 5-Methyluridine | 2.743 | 0.009 | 0.074 | HMDB00884 | Methylated nucleoside |
| 5’-Methylthioadenosine | −0.733 | 0.022 | 0.120 | HMDB01173 | AA metabolism/Cys, Met |
| 2-Aminoisobutyric acid | 1.458 | 0.030 | 0.140 | HMDB01906 | Nucleotide/Pyrimidine metabolism |
| Pseudouridine | 1.573 | 0.027 | 0.130 | HMDB00767 | Nucleotide/Pyrimidine metabolism |
| Succinylcarnitine | 4.220 | 0.002 | 0.030 | HMDB61717 | Acyl carnitine |
| Isovalerylcarnitine | 1.954 | 0.023 | 0.120 | HMDB00688 | Acyl carnitine |
| Arachidonate | −1.221 | 0.001 | 0.025 | HMDB60102 | Lipids/phospholipids, ligand |
| o-phosphoethanolamine | 1.483 | 0.001 | 0.025 | HMDB00224 | Glycerophospholipid modification/metabolism |
| ethanolamine | 1.647 | 0.011 | 0.081 | HMDB00149 | Glycerophospholipid modification/metabolism |
| Glycerol-3-P | 1.276 | 0.016 | 0.104 | HMDB00126 | Lipids/Glycerollipid |
| Reduced glutathione | 0.926 | 0.025 | 0.123 | HMDB00125 | Oxidative Damage |
| Putrescine | −2.930 | 0.001 | 0.025 | HMDB01414 | Polyamine metabolism |
| Sorbitol | −1.055 | 0.022 | 0.120 | HMDB00247 | Sugar |
| Riboflavin | −1.220 | 0.005 | 0.051 | HMDB00244 | Vitamin |
| Suberic acid | −0.650 | 0.049 | 0.189 | HMDB00893 | Fatty acid metabolism |
| Inositol | 1.689 | 0.007 | 0.062 | N/A | Glucose/inositol metabolism |
All major metabolites analyzed in the samples are listed and arranged by the pathways they are involved in.