Table 1.

Main protein partners involved in the anticarcinogenic molecular functions of WWOX (nd: not defined, P: proline, Y: tyrosine, S: serine, L: leucine, A: alanine, X: any amino acid).

Molecular Partner	WWOX Domain Involved	Partner Domain Involved	Complex Localization	Involved in	Reference
p53	nd	nd	nucleus	apoptosis	[37]
p73	nd	PPPY487	cytoplasm	apoptosis	[38]
TRADD	nd	nd	nd	TNF signaling	[55]
TRAF2	nd	nd	nucleus	TNF signaling	[55]
CREB	WW	nd	nucleus	apoptosis	[56]
Hyal-2	WW1	nd	Membrane, nucleus, cytoplasm	cell death	[57,58]
SMAD4	WW1	nd	nucleus	cell death	[57,58]
MEK1	WW and SDR	nd	lysosome	apoptosis	[59]
SMAD3	WW1	PPGY184	cytoplasm	TGFβ1 signaling	[34]
Dvl-2	WW1	PPPY568	cytoplasm	Wnt signaling	[60]
BCL9-2	WW1	PPPY561	nucleus	Wnt signaling	[61]
JAK2	WW1	nd	cytoplasm	JAK2/STAT3 signaling	[15]
STAT3	WW1	nd	cytoplasm	JAK2/STAT3 signaling	[15]
AP-2γ	WW1	PPPY64	cytoplasm	transcription	[62]
ERBB4	WW1	PPIY1037, PPPY1285	cytoplasm	transcription	[63]
C-JUN	WW1	PPPY64	cytoplasm	transcription	[64]
RUNX2	WW1	nd	nucleus	transcription	[65]
ATM	WW1	nd	nd	DNA repair response	[66]
BRCA1	WW1	nd	nd	DNA repair response	[67]
ITCH	WW1	LPXY623 and LPXY839	nucleus	DNA repair response	[8,66]
EZRIN	WW1	PPPPPPPVY477	Apical membrane	Signal transduction	[68]
VOPP1	WW1	PPPY165	cytoplasm	Protein trafficking/sorting	[14]
TMEM207	nd	PPPY139	cytoplasm	Protein trafficking/sorting	[69]
SEC23IP	WW1	PPSY167	nd	Protein trafficking/sorting	[11]
SCAMP3	WW1	PPAY53 or LPSF141	nd	Protein trafficking/sorting	[11]
LITAF	WW1	PPSY23	Golgi apparatus	Protein trafficking/sorting	[70]