Figure 4.
IMiDs mediate indirect augmentation of NK cell function. IMiDs act on IL-2 transcription in T cells to induce the production of TNF-α and IFN-γ and the proliferation of NK cells. Abbreviations: IFN-γ, interferon-γ; IMiD, immunomodulatory imide drugs; IL-2, interleukin-2; TNF-α, tumor necrosis factor-α.