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. 2021 Apr 24;10(5):516. doi: 10.3390/pathogens10050516

Figure 2.

Figure 2

Correlative light fluorescence and electron microscopy of SARS-CoV-2 infected Vero E6 cells. Confocal laser scanning microscopy image of 100-nm-thick ultra-thin section (Z maximal projection) of SARS-CoV-2-infected Vero E6 cells (A), with DNA stained with Hoechst 33342 (blue) and SARS-CoV-2 particles labelled with anti-SARS-CoV-2 spike protein (red). Scanning electron microscopy images (B,C) of the ultra-thin section shown in (A). The boxed region of interest in (A) is shown at a higher magnification in (B). Clusters of SARS-CoV-2 –like particles can be seen in the cell shown in (B) (arrows). Boxed region in (B) is zoomed in (C) showing SARS-CoV-2–like particles (arrow). Scale bars (A–C) of 20 µm, 5 µm and 1 µm respectively.