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. 2021 Apr 27;11(5):396. doi: 10.3390/life11050396

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© 2021 by the author.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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The strand structures of the A chain in blue and B chain in cyan of human-α -thrombin complexed with hirudin in light green. Ile^1′ and the most likely site of a short hydrogen bond (SHB) occurring in the thrombin-r-hirudin complex, residues 55 to 65 of r-hirudin engaged with Arg⁷⁵ and Arg⁷⁷ of thrombin, are labeled. The image is from the Protein Data Bank PDB file 4HTC [129] modeled with Jmol Version 12.0.41.