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The ability to penetrate the skin in vitro was evaluated by introducing microneedles before and after insertion into the porcine cadaver skin. Skin surface with or without microneedles’ administration was assessed by (a) digital color camera; (b,c) with different scales by using SEM; (d) FITC microneedle section, and (e) the histological section using a confocal laser-scanning microscope (scale bar equals 250 µm).
