Table 2.
Significantly abundant transcripts in the blood of patients with Ebstein’s anomaly compared to healthy controls as determined by microarray.
| Human Symbol | Gene ID | Median Ebstein’s Anomaly | Median Controls | Fold Change | Regulation | Adjusted p-Value |
|---|---|---|---|---|---|---|
| KANK4 (KN motif and ankyrin repeat domains 4) | 163782 | 7.59 | 6.45 | 2.71 | Higher | 0.0400 |
| ADGRE4P (adhesion G protein-coupled receptor E4, pseudogene) | 326342 | 5.10 | 3.58 | 2.53 | Higher | 0.0383 |
| KCNG1 (potassium voltage-gated channel modifier subfamily G member 1) | 3755 | 6.41 | 5.22 | 2.48 | Higher | 0.0383 |
| IGF2R (insulin-like growth factor 2 receptor) | 3482 | 10.29 | 9.49 | 2.06 | Higher | 0.0404 |
| BAZ2A (bromodomain adjacent to zinc finger domain 2A) | 11176 | 8.68 | 7.70 | 1.95 | Higher | 0.0082 |
| BACE2 (beta-secretase 2) | 25825 | 8.92 | 8.11 | 1.91 | Higher | 0.0400 |
| PGD (phosphogluconate dehydrogenase) | 5226 | 11.50 | 10.55 | 1.83 | Higher | 0.0404 |
| KDM1A (lysine demethylase 1A) | 23028 | 5.86 | 5.12 | 1.82 | Higher | 0.0065 |
| RIOK1 (RIO kinase 1) | 83732 | 7.42 | 6.75 | 1.81 | Higher | 0.0161 |
| PRPF38B (pre-mRNA processing factor 38B) | 55119 | 7.36 | 6.60 | 1.73 | Higher | 0.0383 |
| ITGAM (integrin subunit alpha M) | 3684 | 10.80 | 9.92 | 1.72 | Higher | 0.0383 |
| CCNY (cyclin Y) | 219771 | 9.65 | 8.84 | 1.68 | Higher | 0.0383 |
| ZFP91 (ZFP91 zinc finger protein, atypical E3 ubiquitin ligase) | 80829 | 8.40 | 7.64 | 1.68 | Higher | 0.0169 |
| ARID1A (AT-rich interaction domain 1A) | 8289 | 8.19 | 7.52 | 1.66 | Higher | 0.0457 |
| LASP1 (LIM and SH3 protein 1) | 3927 | 11.34 | 10.78 | 1.59 | Higher | 0.0065 |
| VPS35 (VPS35 retromer complex component) | 55737 | 9.87 | 9.24 | 1.59 | Higher | 0.0082 |
| PAK1 (p21 (RAC1) activated kinase 1) | 5058 | 11.68 | 11.15 | 1.55 | Higher | 0.0383 |
| RBM23 (RNA binding motif protein 23) | 55147 | 8.40 | 7.81 | 1.54 | Higher | 0.0400 |
| CUX1 (cut like homeobox 1) | 1523 | 8.89 | 8.29 | 1.53 | Higher | 0.0457 |
| WDR1 (WD repeat domain 1) | 9948 | 9.08 | 8.58 | 1.52 | Higher | 0.0090 |
| CACUL1 (CDK2 associated cullin domain 1) | 143384 | 8.47 | 7.87 | 1.52 | Higher | 0.0224 |
| CHD4 (chromodomain helicase DNA binding protein 4) | 1108 | 9.15 | 8.68 | 1.51 | Higher | 0.0400 |
| PSME3 (proteasome activator subunit 3) | 10197 | 9.16 | 8.57 | 1.51 | Higher | 0.0383 |
| VPS26B (VPS26, retromer complex component B) | 112936 | 9.30 | 8.78 | 1.51 | Higher | 0.0191 |
| IL17RA (interleukin 17 receptor A) | 23765 | 11.95 | 11.50 | 1.50 | Higher | 0.0383 |
| SCRN3 (secernin 3) | 79634 | 5.19 | 6.43 | 0.44 | Lower | 0.0400 |
| SLC9A4 (solute carrier family 9 member A4) | 389015 | 8.48 | 9.15 | 0.59 | Lower | 0.0383 |
| PRKAA2 (protein kinase AMP-activated catalytic subunit alpha 2) | 5563 | 4.04 | 4.67 | 0.59 | Lower | 0.0404 |
| LCN8 (lipocalin 8) | 138307 | 4.35 | 4.98 | 0.60 | Lower | 0.0404 |
An un-paired two-tailed t-test was used to calculate the p-value. Benjamini–Hochberg False Discovery Rate (FDR) correction was used to adjust the p-value. Significant changes in abundance levels are shown with an adjusted p-value < 0.05 and fold change (FC) ≥ 2.