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. 2021 Apr 24;9(5):465. doi: 10.3390/biomedicines9050465

Figure 5.

Figure 5

DAT hypofunction influences tachykininergic neurotransmission. (A) Tachykininergic nerve-evoked contractions induced by 10 Hz-EFS, in NANC condition with or without L-NAME or L732138 in isolated ileal preparations of WT and DAT+/− mice. (B) Representative confocal microphotographs showing the distribution of substance P (green) and HuC/D (red, pan-neuronal marker) and (C) substance P density index in LMMP preparations of WT and DAT+/− mice. Scale bars = 22 μm. Data are reported as mean ± SEM. * p < 0.05, ** p < 0.01, *** p < 0.001 vs. WT mice; °° p < 0.01, °°° p < 0.001 vs. respective control in absence of antagonists; #p < 0.05 vs. respective control in NANC condition; §§ p < 0.01, §§§ p < 0.001 vs. respective control with L-NAME. n = 5 mice/group.