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. 2021 May 25;26(10):2439–2444. doi: 10.1016/j.drudis.2021.05.012

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Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Distribution of compounds screened in the anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) high-throughput screening (HTS) assays. The radar plot shows the number of compounds screened in each of the five assays that cover different stages in the SARS-CoV-2 life cycle, such as viral entry into host cells [angiotensin-converting enzyme 2 (ACE2) assay and Spike-ACE2 assay], viral replication [3-chymotrypsin-like protease (3CL) assay], in vitro infectivity [pseudotyped particle (PP) entry assay], and live virus infectivity [cytopathic effect (CPE) assay]. In the plot, each slice represents an assay, and the radius of the slice is proportional to the number of compounds screened in the assay.