Figure 2.

Activity profiles of compounds in anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) high-throughput screening (HTS) assays. In the heat map, each row is a compound, and each column is an assay readout. The colors of the heat map range from blue to red based on compound activity. Blue colors indicate inhibitors, and red colors indicate activators. Gray colors indicate missing values (not tested). Compounds are grouped into clusters of similar activity profiles. Compounds were assigned to different clusters based on the similarity of their activities using R package ‘pheatmap’ with its default clustering method (complete) and distance function (Euclidean). Abbreviations: 3CL, 3-chymotrypsin-like protease; ACE2, angiotensin-converting enzyme 2; CPE, cytopathic effect; PP, pseudotyped particle.