Table 1.
Overview of HTS assays for the identification of anti-SARS-CoV-2 compounds.
| Assay name | Abbreviated name | Assay type | Target category | Cell line | Refs |
|---|---|---|---|---|---|
| ACE2 activity assay | ACE2 assay | Biochemical | Viral entry | N/A | 17 |
| Spike-ACE2 protein–protein interaction assay | Spike-ACE2 | Proximity | Viral entry | N/A | 16 |
| 3CL protease activity assay | 3CL assay | Biochemical | Viral replication | N/A | 19 |
| Pseudotyped particle entry assay | PP entry | Cell based | In vitro infectivity | Vero E6 | 15 |
| Cytopathic effect reduction assay | CPE assay | Cell viability | Live virus infectivity | Vero E6 | 21 |