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. 2021 May 21:1–12. doi: 10.1080/08923973.2021.1925293

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This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.

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Figure 2. — Inhibitory effects of tranilast on inflammation, to manage COVID‐19. Studies have shown that SARS-CoV-2 elevates inflammation and activates NLRP3 inflammasome, which subsequently lead to a cytokine storm and destructive inflammation as well as causing ALI/ARDS in patients with COVID‐19. Tranilast can potentially play an effective role on the regulation of immune system, NLRP3 inflammasome, and inflammation, and provide support for Patients with both severe and moderate COVID‐19.