Skip to main content
. 2021 Apr 28;7(5):343. doi: 10.3390/jof7050343

Figure 4.

Figure 4

Studies of alkyl side chains on PQS. Dose-response assays. (A–D) are C1-PQS, C3-PQS, C5-PQS, C9-PQS respectively, tested against preformed 10AF biofilm, DMSO control shown. (A) Twofold dilutions C1-PQS 50 to 0.2 μg/mL were made. Dilutions 12.5 to 0.2 μg/mL produced slight and insignificant (p > 0.05) inhibition compared to control, and not different from each other (not shown). Only at 25 and 50 μg/mL was inhibition significant, and only at p < 0.05. (B) Same plan as in A, C3-PQS; 0.2 μg/mL produced slight and insignificant (p > 0.05) inhibition, and 0.39 to 50 μg/mL were all inhibitory compared to control (p < 0.01) and not significantly different from each other in effect. (C) Same plan as in A, C5-PQS. All dilutions were inhibitory (p < 0.05) compared to control, but were not different from each other. (D) Same plan as in A, C9-PQS. Slight dose-response, as shown. All dilutions were inhibitory compared to controls, but were not significantly different from each other; 0.2 to 0.78 μg/mL were p < 0.05 compared to controls, and 1.56 to 50 μg/mL were p < 0.001 compared to controls.