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. 2021 Apr 28;7(5):343. doi: 10.3390/jof7050343

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Studies of alkyl side chains on PQS. Effects in hypoxic environment. All molecules tested at 1.56 μg/mL. DMSO control results same as ethanol control. (A) Target 10AF. C1-PQS appears to boost slightly, compared to controls. C9-PQS and PQS inhibit significantly (both p < 0.001) compared to controls. PQS more inhibitory compared to C1-PQS, C3-PQS, C5-PQS, C9-PQS, respectively p < 0.001, p < 0.001, p< 0.05, p > 0.05. (B) Target Af293. C3-PQS, C5-PQS, C9-PQS, PQS all inhibit (p < 0.001) compared to controls, C1-PQS is p > 0.05 compared to controls. PQS more inhibitory compared to C1-PQS, C3-PQS, C5-PQS (p < 0.001 for all), and C9-PQS (p < 0.01).