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. 2021 Apr 24;10(5):660. doi: 10.3390/antiox10050660

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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(a) Rats received vehicle or 1 g/kg acetaminophen (APAP) after CeO₂NP treatment. The top panels show hematoxylin-eosin stained liver sections. The bottom panels show immunostaining for Ki-67 (green) used as a marker of hepatocellular proliferation. Magnification: 100×. (b) Western blot for IκβBα expression in the HepG2cell line treated with vehicle or CeO₂NP. (c) Transcription factor immunosorbent assay for p65 activity in the cell line HepG2 treated with vehicle or CeO₂NP (adapted from reference [68]).