Figure 3.

Glycan engagement of BKPyV. (a) Capsid structure of BKPyV (PDB ID 6ESB). The capsid is represented in the gray cartoon, except for the highlighted pentamer, where VP1 monomers are displayed as ribbons in different shades of blue. (b) Top view of BKPyV VP1 pentamers in interaction with GT1b. The pentamer is displayed as a surface colored in different shades of blue for each subunit. The double sialic acid part of GT1b is represented as yellow sticks. (c) Surface representation of BKPyV VP1 pentamers, in blue, associated with the difference map for heparin, in yellow (generated through subtraction of the unliganded VLP map (EMD-3946) from the heparin-VLP map (EMD-3945)). Figures were created using PyMOL [23] and Chimera [51].