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. 2021 Apr 28;12(5):662. doi: 10.3390/genes12050662

Figure 2.

Figure 2

WT HRAS+NRAS knockdown correlates with mutant KRAS knockdown in KRAS-mutated colorectal and pancreatic cancer cell lines. (A,B) Gene effect of combined RNAi knockdown (Broad, Novartis, Marcotte, A) or CRISPR-mediated deletion (Avana, B) of KRAS, HRAS, or NRAS from the DepMap Portal data set in KRAS-mutated colorectal, NSCLC, and pancreatic cancer cell lines. (C,D) Effect of siRNA knockdown of mutant KRAS or both non-mutated WT RAS (HRAS and NRAS) genes (C) or linear correlation between mutant KRAS and WT RAS knockdown (D) from the siREN screen [23] in KRAS-mutated colorectal, NSCLC, and pancreatic cancer cell lines. Pearson correlation coefficient is shown. Each symbol indicates an individual cell line.