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Fusion inhibitors. Various vulnerable sites of HIV-1 entry, including the BMS compound binding site in gp120 (pdb ID: 5U7M; [142]), the MPER (pdb ID: 6V4T; [147]), the CCR5 TM pocket (pdb ID: 4MBS; [15]), and the T20 binding groove on the HR-1 trimer (pdb ID: 5ZCX; [148]), are targeted by different entry/fusion inhibitors, including BMS-378806, S2C3, Maraviroc, and T20/Enfuvirtide.
