Figure 7.
A, B, There was no effect of Tat or morphine exposure on the VV of hippocampal areas CA1, CA2, or the dentate gyrus (DG); however, the volume of CA3 was significantly increased by Tat induction regardless of morphine exposure (see Table 1). Importantly, the measurements of dendritic spine density (Figs. 4, 5) were not distorted by morphine-dependent or Tat-dependent alterations in the volume of hippocampal area CA1. Images show representative Hoechst 33342-stained, 40-μm-thick coronal sections of the hippocampus from Tat− (A) and Tat+ (B) mice used for stereology.