Table 2.
The frequencies of the BDNF rs6265 and BDNF rs56164415 genotypes and alleles in 643 veterans with PTSD and 121 control subjects. The data is shown as total number N (frequency in percentages). p values in bold represent statistical significance.
| SNP | Genotype/Allele | Control Subjects | Subjects with PTSD | Total | Statistics |
|---|---|---|---|---|---|
| BDNF rs6265 | AA | 4 (3.3) | 18 (2.8) | 22 (2.9) | χ2 = 1.379; df = 2; p = 0.502 |
| GA | 48 (39.7) | 222 (34.5) | 270 (35.3) | ||
| GG | 69 (57.0) | 403 (62.7) | 472 (61.8) | ||
| A carriers | 52 (43.0) | 240 (37.3) | 292 (38.2) | χ2 = 1.377; df = 1; p = 0.241 |
|
| GG | 69 (57.0) | 403 (62.7) | 472 (61.8) | ||
| A | 56 (23.1) | 258 (20.1) | 314 (20.5) | χ2 = 1.182; df = 1; p = 0.277 |
|
| G | 186 (76.9) | 1028 (79.9) | 1214 (79.5) | ||
| BDNF rs56164415 | CC | 105 (86.8) | 473 (73.6) | 578 (75.6) | χ2 = 58.335; df = 2; p < 0.001 |
| CT | 2 (1.7) | 159 (24.7) | 161 (21.1) | ||
| TT | 14 (11.6) | 11 (1.7) | 25 (3.3) | ||
| T carriers | 16 (13.3) | 170 (26.4) | 186 (24.4) | χ2 = 9.653; df = 1; p = 0.002 |
|
| CC | 105 (86.8) | 473 (73.6) | 578 (75.6) | ||
| C | 212 (87.6) | 1105 (85.9) | 1317 (86.2) | χ2 = 0.482; df = 1; p = 0.488 |
|
| T | 30 (12.4) | 181 (14.1) | 211 (13.8) |
BDNF—brain derived neurotrophic factor; χ2 = chi-square test.