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HSP90 inhibitors affect notch signaling in TNBC cells. Celastrol and triptolide inhibited notch signaling by decreasing the expression level of Notch ligand, Jagged-1, NICD 1, and Notch downstream target proteins HES1 and HEY1 in TNBC cells. Left panel shows blots from cells grown in 2D cell and right panel shows those from mammospheres. (A) MDA-MB-231 cells, (B) BT20 cells, and (C) PD-TNBC cells.
