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. 2021 May 25;108:454–460. doi: 10.1016/j.ijid.2021.05.055

Table 2.

Secondary endpoints.

Control Nintedanib P Value
N = 30 N = 30
Ventilator-free days within 28 days 12 (0–17) 17 (0–21) 0.038
Percentage of high-attenuation areas on CT
 Induction of mechanical ventilation (%) 29.1 (20.3–33.1) 30.8 (20.9–46.7) 0.651
 Liberation from mechanical ventilation (%) 38.7 (20.9–45.6) 25.7 (9.4–34.6) 0.027
Gastrointestinal adverse events
 Mild events 27 (90%) 25 (83.3%) 0.448
 Moderate events 6 (20%) 9 (30%) 0.371
 Severe events 3 (10%) 2 (6.7%) 0.640
Acute liver failure
 Mild 20 (66.7%) 24 (80%) 0.243
 Moderate 6 (20%) 11 (36.7%) 0.158
 Severe 2 (6.7%) 2 (6.7%) 1.00

CT, computed tomography.