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. 2021 May 25;13:116. doi: 10.1186/s13148-021-01103-8

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Epigenetics changes during the proliferative and secretory phases in endometrial cells. a. During the proliferative phase, the enrichment of H3K27me3 on the HOXA10, PRL, and IGFBP-1 promoters in endometrial stromal cells (ESC) is reported, which is consistent with the lack of expression of these genes. Also, an increase in the expression of EZH2, which catalyzes the H3K27me3 modification, is observed. b. A decrease in the enrichment of H3K27me3 in the HOXA10, PRL, and IGFBP-1 promoters in decidual stromal cells (DSC) during the secretory phase is reported; consequently, an increase in the expression of these genes is observed. Furthermore, a decrease in the expression of EZH2 during decidualization is observed in DSC. During the secretory phase, some miRNAs, lncRNAs, and the proteins involved in their biogenesis increase their expression compared to the proliferative phase, such as miRNA-222, miR-543, and DICER in DSC, and miR-29c, DROSHA, H19, and PTENP1 in endometrial epithelial cells (EEC)