Table 5.
Diagnostic value of biomarkers for acute and chronic PJI treated with DAIR
| Values of biomarkers | Acute PJI (n = 23), Reinfection (n = 11) | Chronic PJI (n = 21), Reinfection (n = 15) |
|---|---|---|
| ESR | ||
| AUC | 0.63 | 0.56 |
| Optimal cutoff | 22 mm/h | 20 mm/h |
| Youden index | 0.33 | 0.23 |
| Sensitivity | 90.91% | 66.00% |
| Specificity | 41.67% | 16.66% |
| PPV | 58.80% | 66.66% |
| NPV | 83.30% | 16.66% |
| CRP | ||
| AUC | 0.56 | 0.58 |
| Optimal cutoff | 58.62 mg/L | 16.50 mg/L |
| Youden index | 0.23 | 0.37 |
| Sensitivity | 72.73% | 53.33% |
| Specificity | 50.00% | 66.66% |
| PPV | 57.10% | 80.00% |
| NPV | 66.70% | 36.36% |
| FIB | ||
| AUC | 0.75 | 0.81 |
| Optimal cutoff | 3.32 g/L | 3.94 g/L |
| Youden index | 0.65 | 0.63 |
| Sensitivity | 81.82% | 80.00% |
| Specificity | 83.33% | 66.66% |
| PPV | 81.80% | 85.71% |
| NPV | 83.30% | 57.14% |
ROC Receiver operating characteristic, ESR Erythrocyte sedimentation rate, CRP C-reactive protein, FIB Fibrinogen, AUC Area under the curve, PPV Positive predictive value, NPV The negative predictive value