Table 1.

Cyanobacterial derived natural products used in clinical tests.

Compound Name (No.)/Chemical Class	Cyanobacteria Species/Source	Type of Activity	Clinical Status/Study Type	References
Dolastatin 10 (44)/Depsipeptides	Symploca sp.	Sarcoma, Leukemia, Lymphoma, Liver Cancer, and Kidney Cancer, among others.	Drug Investigational	[92,93,94,95,96,97,98,99,100]
		Leukemia Lymphoma	Drug Intervention Phase II
		Prostate Cancer	Drug Intervention Phase II
		Kidney Cancer	Drug Intervention Phase II
		Extrahepatic Bile Duct Cancer Gallbladder Cancer Liver Cancer	Drug Intervention Phase II
		Ovarian Cancer Sarcoma	Drug Intervention Phase I
		Leukemia Myelodysplastic Syndromes	Drug Intervention Phase I
		Pancreatic Cancer	Drug Phase II Intervention
Cemadotin (47), Tasidotin (48) and Synthadotin (49) (Derived from dolastatin 15 (45)/Depsipeptide	Dolabella auricularia and cyanobacteria Symploca (later)	Melanoma	Drug: ILX651 Intervention Phase II
		Hormone-refractory Prostate Cancer		[101,102,103,104]
		Non-Small-Cell Lung Carcinoma
Cryptophycin 52 (43)/(Synthetic analog of cryptophycin 1 (5) Depsipeptides	Nostoc sp., terrestrial cyanobacteria	Schizophrenia	Cognitive remediation therapy, Intervention Not Applicable Phase	[101,105,106]
		Hypertension Metabolic Disorder	Drug: losartan potassium (+) hydrochlorothiazide, Intervention Phase III
Toyocamycin (52)/Pyrrolopyrimidine nucleoside	Streptomyces toyocaensis Cyanobacteria	Non-Small-Cell Lung Carcinoma	Drug Experimental	[101,107]
Phytoalexin (53)/Polysaccharides	Scytonema ocellatum	Type 2 Diabetes (RED)	Drug Phase I Intervention	[108,109]
Soblidotin (46)/(Synthetic analog of dolastatin 10) Depsipeptides		Sarcoma	Drug Intervention Phase II	[101,110]
		Lung Cancer
Phycocyanin (54)/A pigment-protein complex	Spirulina	Chronic Periodontitis	Drug: Spirulina capsules, Intervention Phase IV	[111,112,113]
		Metabolic Syndrome	Dietary Supplement: Spirulysat® Dietary Supplement: Placebo Intervention Not Applicable Phase
Anatoxins-a (51)/ Peptides	Anabeana circinalis	Amyotrophic Lateral Sclerosis	Recruiting Patient Registry Intervention	[114,115]
Bacteriocins/Peptides	43 different cyanobacteria viz., Prochlorcoccus marinus, Synechococcus sp., Cyanothece sp., Microcystis aeruginosa, Synechocystis, Arthospira, Nostoc, Anabaena, Nodularia	Ventilator Associated Pneumonia	Lactobacillus bacteria Intervention	[116,117,118,119,120]
		Colic, Infantile Probiotic Gut Microbiome Bifidobacterium Breve	Drug Intervention Phase IV
		Healthy	Plantaricin A—rejuvenating cream, antioxidant serum, rejuvenating serum Intervention Phase III
		White Spot Lesion of Tooth Long Term Adverse Effects Caries, Dental Orthodontic Appliance Complication	Drug: Probiotic Toothpaste Drug: Dr. Reddy’s Clohex Other: Control Group Intervention Phase I and II
Curacin (50)/Lipopeptides	Lyngbya majuscule		In vivo animal trails. Preclinical Phase (but it served as a lead compound)	[91]
Cyanovirin-N (40) (CVN)/A protein	Nostoc ellipsosporum	Inhibiting HIV cell entry in a highly specific manner.	Preclinical Phase	[121]