Table 13.
Summary of results from ex vivo studies to evaluate intestinal permeability of nursery pigs with Ussing chambers.
| References | Age | Intestinal Segment | Probes (Markers) 1 | Findings | |||||
|---|---|---|---|---|---|---|---|---|---|
| HRP | Man | GlySar | Na-Flu | Na+-Gluc | Na+-Glut | ||||
| [280] | 26 | Jejunum | X | X | X | X | Postweaning feed intake level did not change gut permeability in nursery pigs | ||
| [281] | 28 | Jejunum | X | X | Intestinal molecular permeability was not affected by the age of weaning and creep feeding | ||||
| [282] | 28 | Jejunum | X | Dietary modification from milk- to grain-based sources did not affect HRP fluxes in nursery pigs | |||||
| [283] | 25 | Jejunum | X | X | Intestinal macromolecular permeability was not affected by supplemental dietary tryptophan | ||||
| [284] | 26 | Jejunum | X | X | Intestinal permeability was not different between piglets fed a high-lactulose and low-protein (HL/LP) diet compared with piglets fed control (milk-based) diet | ||||
| [285] | 26 | Jejunum | X | X | Feeding dry pellets elevated transcellular permeability compared with wet feeding | ||||
| Jejunum | X | X | |||||||
| [286,287] | 28 | jejunum | X | X | X | Paracellular permeability was not affected by supplementation of various probiotics (E. farcium and B. cereus var. toyoi) | |||
| [288] | 24 | Ileum, Colon | X | X | Feeding diets containing 2.5% and 5% spray-dried porcine plasma reduced ileal permeability of pigs on day 7 postweaning | ||||
| [289] | 28 | Ileum | X | X | Increasing dietary Zn level from 100 to 2500 ppm at weaning increased intestinal permeability and reduced diarrhea | ||||
| [290] | 28 | Jejunum | X | X | Dietary copper disturbed intestinal-barrier function by increasing transepithelial conductance | ||||
| [291] | 7 | Ileum | X | X | Intestinal permeability increased by 89% in the ileum of piglets deficient in dietary threonine (6.5 g/kg) compared with piglets fed the control diet containing 9.3 g/kg threonine | ||||
| [292] | 14–17 | Jejunum | X | Long-chain (n-3) PUFA supplementation of maternal diets had no effect on total or passive ion transport of their progeny | |||||
| [293] | 15–19 | Jejunum | X | Feeding maternal diets containing long-chain (n−3) PUFA resulted in upregulated glucose flux in piglet jejunum | |||||
1 HRP = horseradish peroxidase; Man = mannitol; GlySar = glycylsarcosine; Na-Flu = sodium-fluorescein isothiocyanate; Na+-gluc = sodium-dependent glucose; Na+-glut = sodium-dependent glutamine.