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. 2021 Apr 28;13(5):777. doi: 10.3390/v13050777

Table 1.

Overview of orthohepadnaviruses found in primates. Various primates contain species-specific HBV variants that can potentially undergo interspecies transmission. A major block for natural HBV infections in certain non-human primates is the expression of particular amino acid residues in the NTCP receptor. Potential recombination events have been evidenced in humans, chimpanzees, gibbons, and gorillas.

Natural
HBV Variant:		 Permissive to Barrier for Natural HBV Infection: Potential Recombination Events with:
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Human		 HBV HBV None chHBV;
gibHBV
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Chimpanzee		 chHBV HBV
chHBV		 None HBV;
gorilla-specific
HBV variants
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Cynomolgus
monkey		 Possibly
mcHBV		 HBV
(in hNTCP-expressing hepatocytes)		 158R residue of NTCP receptor N/A
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Woolly monkey		 WMHBV WMHBV NTCP receptor N/A
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Rhesus macaque		 N/A HBV
(in hNTCP-expressing hepatocytes)		 158R residue of NTCP receptor N/A
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Gorilla		 Gorilla-specific
HBV		 Gorilla-specific
HBV;
Possibly chHBV		 N/A chHBV
Inline graphic
Gibbon		 gibHBV gibHBV N/A HBV
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Squirrel monkey		 N/A WMHBV Unknown (contains 158G of NTCP receptor, like human) N/A
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Spider monkey		 N/A WMHBV Unknown N/A

chHBV, chimpanzee HBV; mcHBV, cynomolgous HBV; WMHBV, woolly monkey HBV; gibHBV, gibbon HBV; hNTCP, human sodium taurocholate co-transporting polypeptide.