Figure 4.

Crystal structure of CSFV Npro. (A) Cartoon representation of Npro (PDB code 4H9J). On the left, Npro is coloured from the N terminus (blue) to the C terminus (red). On the right, Npro is coloured according to sequence conservation from white (non-conserved) to red (conserved). (B) Location of important residues in Npro, H69 and C89 (left, APPV numbering) and the TRASH motif (right) are drawn as sticks. Figure 4, Figure 5, Figure 6, Figure 7 and Figure 8 were prepared with PyMOL (The PyMOL Molecular Graphics System, Schrödinger, LLC., New York, NY, USA).