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Role of syntaxin-5, syntaxin-1a and VAMP8 in AD. (a) Syntaxin-5 (violet) regulates membrane fusion at ER (pink) and it is responsible for Aβ42 peptide (yellow) accumulation. (b) Syntaxin-1a (red) interacts with Aβ monomers and oligomers (from yellow to brown), which block the SNARE complex formation and exocytosis. (c) VAMP8 (blue) is localized at vesicles fusing to the PM and regulates tau secretion.
