Table 1.
Classification of human SNAREs and their involvement in neurodegenerative diseases.
| SNARE Type | Name of the SNARE Protein (Alternative Name) |
Neurodegenerative Disease |
References |
|---|---|---|---|
| Qa (syntaxins) | Syntaxin-1 (HPC-1) | AD, PD, ALS | [30,40,41,47,48,49,50,51,52,53,54,55] |
| Syntaxin-2 (Epimorphin) | |||
| Syntaxin-3 | |||
| Syntaxin-4 | |||
| Syntaxin-5 | AD, PD | [42,44,56,57,58] | |
| Syntaxin-7 | |||
| Syntaxin-11 | |||
| Syntaxin-13 (Syntaxin-12) | |||
| Syntaxin-16 | |||
| Syntaxin-17 | AD, PD | [43,45] | |
| Syntaxin-18 | |||
| Qb | GS-27 | ||
| GS-28 | |||
| Vti1a | |||
| Vti1b | |||
| Qc | BET1 | AD | [44] |
| GS-15 | |||
| Slt1 | |||
| Syntaxin-6 | PD | [59] | |
| Syntaxin-8 | |||
| Syntaxin-10 | |||
| Qb-c | SNAP-23 (Syndet) | ||
| SNAP-25 | AD; PD; ALS | [30,40,43,47,48,50,53,60,61,62] | |
| SNAP-29 (GS-32) | |||
| R | VAMP1 (Synaptobrevin 1) | ||
| VAMP2 (Syb 2) | AD; PD; ALS | [30,40,47,48,53,55,63,64,65,66,67,68] | |
| VAMP3 (Cellubrevin) | |||
| VAMP4 | PD | [59,69] | |
| VAMP5 | |||
| VAMP7 (Ti-VAMP) | PD | [43] | |
| VAMP8 (Endobrevin) | AD, PD | [45,70,71,72] | |
| YKT6P | PD | [46] | |
| SEC22b (ERS-24) | PD | [46] | |
| Unclassified | SEC22a | ||
| SEC22c | |||
| SEC20 (Bnip1) |