Table 3.
Biological pathways showing significant internal correlation structure rewiring in three of the five examined datasets.
| Pathway Name | # Genes | Fisher’s Combined p-Value | Hub Gene(s) in Controls * | Hub Gene(s) in SCZ * |
|---|---|---|---|---|
| MHC class II antigen presentation | 75 | 7.0 × 10−5 | AP1S1, CLTC, KIF3B | DCTN1, KIFAP3, SPTBN2 |
| Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) | 5 | 4.0 × 10−4 | CYP1A2, EPHX2 | CYP1B1, CYP2J2, EPHX2 |
| Glutamate neurotransmitter release cycle | 20 | 0.0015 | SNAP25, RAB3A, SYT1 | PPFIA2, STXBP1 |
| L1CAM interactions | 75 | 0.0019 | CHL1, DLG1, SCN8A | CHL1, DLG3, MAP2K1 |
| GPCR downstream signaling | 258 | 0.0037 | DGKI, SOS1, PRKCE | PDE1A, PRKCE, RGS7 |
| Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor | 13 | 0.0037 | ADAM10, NOTCH3, NOTCH4 | NOTCH1, NOTCH3, UBC |
| a6b1 and a6b4 Integrin signaling | 32 | 0.0050 | PIK3CA, YWHAG | PIK3CA, YWHAB, YWHAG |
| G alpha (i) signaling events | 97 | 0.0056 | ADCY1, CHRM4, GNG13 | GNG11, GNG13, RGS7 |
| FAS signaling pathway | 18 | 0.0056 | CYC1, GSN, MAP2K4 | LMNB2, MAP2K4, MAPK9 |
* The hub genes nominated by different datasets may not be the same, and they were all shown.