Figure 2.

(A) Schematic diagram displaying RBP targeting strategies that may involve RNA-protein or protein-protein interactions, protein aggregation and cell pathways. (B) Current RBP-based targeting therapeutic strategies focus on either the manipulation of a specific RBP or an RBP-RNA interaction and so can be categorised as either direct or indirect approaches, respectively. Direct therapeutic strategies revolve around the knockdown or overexpression of a particular RBP. Indirect approaches, on the other hand, including the use of circular RNA, siRNA, synthetic peptides, oligonucleotide based, aptamers, small molecules, and CRISPR, can be designed to either inhibit the interaction of an RBP with RNA by inducing degradation, to suppress enzymatic activity, to block post transcriptional modifications or through binding to outcompete a chosen RBP. Figure created using Biorender.com.