Table 3.
β and 95% confidence interval (95% CI) for thyroid hormones changes (△THs) according to puberty development by multiple liner regression analyses.
| Group | N(%) a | Median (P25~P75) | β (95% CI) | |
|---|---|---|---|---|
| Model 1 d | Model 2 e | |||
| △TSH (mU/L) | ||||
| PCS changes b | ||||
| lower (△≤1) | 203(46.24) | -0.28(-0.81~0.16) | 0.00 | 0.00 |
| middle (△=2) | 107(24.37) | -0.37(-1.03~0.10) | -0.08(-0.30~0.14) | -0.09(-0.30~0.13) |
| higher (△≥3) | 129(29.38) | -0.56(-1.04~ -0.17) | -0.25(-0.45~ -0.04)* | -0.14(-0.35~0.07) |
| Per-1 SD | – | – | -0.09(-0.19~0.01) | -0.05(-0.15~0.05) |
| Puberty pattern c | ||||
| BPFP+BPFL | 98(22.32) | -0.54(-1.04~ -0.12) | 0.09(-0.19~0.37) | 0.19(-0.10~0.47) |
| BPFT | 62(14.12) | -0.53(-1.13~ -0.24) | 0.02(-0.30~0.33) | 0.07(-0.23~0.38) |
| BLFL | 71(16.17) | -0.57(-1.32~0.08) | 0.00 | 0.00 |
| BLFT | 137(31.22) | -0.27(-0.79~0.12) | 0.28(0.01~0.54)* | 0.24(-0.01~0.50) |
| BTFT | 71(16.17) | -0.21(-0.61~0.37) | 0.58(0.28~0.88)*** | 0.50(0.21~0.80)** |
| △FT3 (pmol/L) | ||||
| PCS changes b | ||||
| lower (△≤1) | 203(46.24) | -0.71(-1.05~ -0.43) | 0.00 | 0.00 |
| middle (△=2) | 107(24.37) | -0.81(-1.18~ -0.57) | -0.14(-0.37~0.10) | -0.14(-0.38~0.10) |
| higher (△≥3) | 129(29.38) | -0.85(-1.19~ -0.42) | -0.19(-0.41~0.03) | -0.24(-0.47~ -0.01)* |
| Per-1 SD | – | – | -0.07(-0.18~0.03) | -0.10(-0.21~0.01) |
| Puberty pattern c | ||||
| BPFP+BPFL | 98(22.32) | -0.72(-1.12~ -0.29) | -0.21(-0.52~0.09) | -0.26(-0.57~0.06) |
| BPFT | 62(14.12) | -0.95(-1.15~ -0.66) | -0.36(-0.70~ -0.02)* | -0.39(-0.73~ -0.04)* |
| BLFL | 71(16.17) | -0.76(-1.06~ -0.48) | 0.00 | 0.00 |
| BLFT | 137(31.21) | -0.80(-1.18~ -0.49) | -0.27(-0.56~0.01) | -0.26(-0.55~0.03) |
| BTFT | 71(16.17) | -0.69(-0.92~ -0.29) | -0.12(-0.45~0.21) | -0.10(-0.42~0.24) |
| △FT4 (pmol/L) | ||||
| PCS changes b | ||||
| lower (△≤1) | 203(46.24) | 1.43(-0.23~2.80) | 0.00 | 0.00 |
| middle (△=2) | 107(24.37) | 1.52(-0.18~3.30) | 0.04(-0.58~0.67) | 0.07(-0.51~0.67) |
| higher (△≥3) | 129(29.38) | 1.80(0.07~3.70) | 0.41(-0.18~1.00) | -0.17(-0.74~0.41) |
| Per-1 SD | – | – | 0.20(-0.08~0.49) | -0.03(0.14~ -0.31) |
| Puberty pattern c | ||||
| BPFP+BPFL | 98(22.32) | 2.06(0.46~3.73) | 0.47(-0.34~1.27) | 0.00(-0.78~0.77) |
| BPFT | 62(14.12) | 2.36(0.51~3.78) | 0.52(-0.38~1.42) | 0.27(-0.58~1.12) |
| BLFL | 71(16.17) | 1.32(-0.39~2.90) | 0.00 | 0.00 |
| BLFT | 137(31.21) | 1.11(-0.26~3.09) | -0.42(-1.17~0.34) | -0.20(-0.91~0.51) |
| BTFT | 71(16.17) | 0.58(-0.50~2.60) | -0.63(-1.50~0.24) | -0.18(-1.01~0.64) |
N(%): The number and proportions of girls with different characteristics;
PCS changes: Changes in puberty category scores (PCS) from baseline to follow-up;
Puberty pattern: “BPFP+BPFL”, pre-pubertal at both baseline and follow-up & pre-pubertal at baseline and late-pubertal at follow-up, respectively; “BPFT, pre-pubertal at baseline and post-pubertal at follow-up, respectively”, “BLFL, late-pubertal at both baseline and follow-up”, “BLFT, late-pubertal at baseline and post-pubertal at follow-up, respectively” and “BTFT, post-pubertal at both baseline and follow-up”;
Model 1: Crude β(95% CI);
Model 2: Adjusted β(95% CI) after age at baseline, area, △BMI, and △WC.
*P < 0.05; **P < 0.01. ***P < 0.001.