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Activation of inward rectification of GIRK1/2 in the CB-GIRK1/2-RGS4 coupling in Xenopus oocytes. (A) Oocytes co-injected with CB1, GIRK1/2, and RGS4 cRNAs, and (B) oocytes co-injected with CB2, GIRK1/2, and RGS4 cRNAs were subjected to a 1-s voltage ramp protocol from −150 to +60 mV from a holding potential of −20 mV. Inward IK,basal was enhanced by exchanging HK to HK plus 1 μM WIN55,212-2. Typical IK,basal and IK,WIN were recorded from three to six different oocytes.
